Tetrabutylammonium Fluoride → HCID 86686338, 화합물

반응식

[Br:1][C:2]1[C:3]([CH2:10]Br)=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8].CCCC[N+](CCCC)(CCCC)CCCC.[F-:29]>>[Br:1][C:2]1[C:3]([CH2:10][F:29])=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8]

참가 물질

반응물 2

HCID 2724141Tetrabutylammonium Fluoride

HCID 86686337HCID 86686337, 화합물

생성물 1

HCID 86686338HCID 86686338, 화합물

실험 절차

A mixture of 3-bromo-2-(bromomethyl)-4,6-dimethylpyridine (1.00 g) and TBAF (17.9 mL, 1 M solution in THF) was stirred at room temperature for two hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 30%) to give the title compound (651 mg).

후처리

concentrationThe reaction mixture was concentrated under reduced pressure
customthe residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 30%)

출처 및 근거

ORD 기록: ord-641ade8db95e44018bf6e263c49f7f37
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08563565B2

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