Tetrabutylammonium Fluoride → 3-Bromo-2-(fluoromethyl)-6-methoxy-4-methylpyridine
반응식
[Br:1][C:2]1[C:3]([CH2:11]Br)=[N:4][C:5]([O:9][CH3:10])=[CH:6][C:7]=1[CH3:8].CCCC[N+](CCCC)(CCCC)CCCC.[F-:30]>>[Br:1][C:2]1[C:3]([CH2:11][F:30])=[N:4][C:5]([O:9][CH3:10])=[CH:6][C:7]=1[CH3:8]참가 물질
3
실험 절차
A mixture of 3-bromo-2-(bromomethyl)-6-methoxy-4-methylpyridine (126 mg) and TBAF (1.71 mL, 1 M solution in THF) was stirred at room temperature for two hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%) to give the title compound (37 mg).
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe resulting residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%)
출처 및 근거
- ORD 기록
- ord-6be50967bf7f4a1a9d22e9f549658854
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08563565B2
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