Dimethylformamide → 3-Bromo-5-fluoro-2-methoxy-4-methylpyridine

HRID 1043919노트

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HRID 1043919 반응식
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[CH3:8].CN([CH:14]=[O:15])C.C[O-].[Na+]>O>[Br:1][C:2]1[C:3]([O:15][CH3:14])=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[CH3:8]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 10942334Sodium MethoxideHCID 73555087HCID 73555087, 화합물

생성물 1

HCID 866863433-Bromo-5-fluoro-2-methoxy-4-methylpyridine

시약·촉매·용매 1

HCID 962Water용매

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온도
80 °C

실험 절차

3-bromo-2-chloro-5-fluoro-4-methylpyridine (340 mg) was added to DMF (1.8 mL). Sodium methoxide (28% solution in methanol, 5.4 mL) was added to the solution, and the mixture was stirred at 80° C. for two hours. Water was added to the reaction mixture. The precipitated solid was collected by filtration to give the title compound (240 mg).

후처리

  1. filtrationThe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-ad0a96bf3f0247ac90b793971266620f
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563565B2

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