1,1-Dimethylethyl (2S)-2-(2-methylpropyl)-1-piperazinecarboxylate → tert-butyl (2S)-2-isobutyl-4-[2-(1-tritylpyrazolo[5,4-b]pyridin-3-yl)thiazol-4-yl]piperazine-1-carboxylate

반응식

Br[C:2]1[N:3]=[C:4]([C:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[N:9]([C:16]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:8]=2)[S:5][CH:6]=1.CC(C)([O-])C.[Na+].[CH2:41]([C@H:45]1[CH2:50][NH:49][CH2:48][CH2:47][N:46]1[C:51]([O:53][C:54]([CH3:57])([CH3:56])[CH3:55])=[O:52])[CH:42]([CH3:44])[CH3:43]>C1(C)C=CC=CC=1.CCOC(C)=O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].CC(OC1C=CC=C(OC(C)C)C=1C1C(P(C2CCCCC2)C2CCCCC2)=CC=CC=1)C>[CH2:41]([C@H:45]1[CH2:50][N:49]([C:2]2[N:3]=[C:4]([C:7]3[C:15]4[C:10](=[N:11][CH:12]=[CH:13][CH:14]=4)[N:9]([C:16]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:8]=3)[S:5][CH:6]=2)[CH2:48][CH2:47][N:46]1[C:51]([O:53][C:54]([CH3:56])([CH3:55])[CH3:57])=[O:52])[CH:42]([CH3:44])[CH3:43]