4-Chloroaniline → (4-Chloro-phenylamino)-phenyl-acetic acid

HRID 1044040

반응식

HRID 1044040 반응식
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1>C(#N)C>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][CH:2]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3]([OH:5])=[O:4])=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 78124-ChloroanilineHCID 97919Bromo(phenyl)acetic acid

생성물 1

HCID 305145(4-Chloro-phenylamino)-phenyl-acetic acid수율 47%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
100 °C

실험 절차

To a solution of α-bromophenylacetic acid (1.00 g, 4.65 mmol) in acetonitrile (20 ml), was added 4-chloro-phenylamine (1.18 g, 9.30 mmol), and the mixture was heated under microwave irradiation at 100° C. for 1 hour (UPLC-MS monitoring: complete conversion). The solvent was evaporated, and the residue was positioned between EtOAc and 1N HCl. The organic phase was dried over Na2SO4, filtered and evaporated to dryness to obtain intermediate I11 (0.57 g; 47% yield).

후처리

  1. customThe solvent was evaporated
  2. dry with materialThe organic phase was dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated to dryness
  5. customto obtain intermediate I11 (0.57 g; 47% yield)

출처 및 근거

ORD 기록
ord-932593593b624f02a12186934c13286b
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563577B2

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