Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

HRID 1044580노트

반응식

HRID 1044580 반응식
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 22707864HCID 22707864, 화합물

생성물 1

HCID 227078634-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl 4-[2-(trifluoromethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (200 mg, 0.61 mmol) in methylene chloride (5 mL) was added trifluoroacetic acid (2.5 mL). After being stirred at room temperature for 45 min, the solution was concentrated to give an oil. MS calculated for C12H12F3N: (M+H) 228; found 228.1.

후처리

  1. concentrationthe solution was concentrated
  2. customto give an oil

출처 및 근거

ORD 기록
ord-6b71f588994b49d683d35f641d06a239
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563582B2

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