2-Methyl-2-(3-nitropropyl)-1,3-dioxolane → 3-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

HRID 1044733노트

반응식

HRID 1044733 반응식
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][N+:10]([O-])=O)[O:6][CH2:5][CH2:4][O:3]1>CO.[Pd]>[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][NH2:10])[O:6][CH2:5][CH2:4][O:3]1

참가 물질

4

반응물 1

HCID 6383462-Methyl-2-(3-nitropropyl)-1,3-dioxolane

생성물 1

HCID 5600073-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar, a mixture of 2-methyl-2-(3-nitro-propyl)-[1,3]dioxolane (1.80 g, 10.27 mmol) and Pd/C 10% (176 mg) in dry MeOH (35 mL) was stirred at rt under atmospheric H2 for 11 h. The reaction mixture was then filtered and concentrated under reduced pressure to give the title compound as a colorless oil. LC-MS-conditions 02: tR=0.25 min; [M+H]+=146.41.

후처리

  1. customIn a flame dried round-bottomed flask equipped with a magnetic stir bar
  2. filtrationThe reaction mixture was then filtered
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2f1e704c1227438da0f54ac674e12714
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563714B2

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