Nitrogen → 1-(2-Bromo-1,3-thiazol-5-yl)ethan-1-one

HRID 1044752

반응식

HRID 1044752 반응식
N#N.[Br:3][C:4]1[S:5][C:6]([CH:9]([OH:11])[CH3:10])=[CH:7][N:8]=1>CC#N.O=[Mn]=O>[Br:3][C:4]1[S:5][C:6]([C:9](=[O:11])[CH3:10])=[CH:7][N:8]=1

참가 물질

5

반응물 2

HCID 947NitrogenHCID 591351941-(2-Bromothiazol-5-yl)ethanol

생성물 1

HCID 575628131-(2-Bromo-1,3-thiazol-5-yl)ethan-1-one

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6342Acetonitrile용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(2-bromo-thiazol-5-yl)-ethanol (14.85 g, 71.37 mmol) in CH3CN (160 mL) was treated at rt with MnO2 (34.47 g, 356.84 mmol) and the reaction mixture was stirred for 20 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow solid. TLC:rf (1:1 hept-EA)=0.54. LC-MS-conditions 02: tR=0.79 min.

후처리

  1. filtrationbefore being filtered through Celite
  2. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-d6181ba5f0ef4e5a8c7052124afbce82
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563714B2

연결된 노트

불러오는 중…