Nitrogen → 1-(4-Chloromethyl-thiazol-2-yl)ethanone

HRID 1044778

반응식

HRID 1044778 반응식
N#N.[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH:10]([OH:12])[CH3:11])[S:8][CH:9]=1>CC#N.O=[Mn]=O>[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([C:10](=[O:12])[CH3:11])[S:8][CH:9]=1

참가 물질

5

반응물 2

HCID 947NitrogenHCID 668198411-(4-Chloromethyl-thiazol-2-yl)-ethanol

생성물 1

HCID 668199771-(4-Chloromethyl-thiazol-2-yl)ethanone

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6342Acetonitrile용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(4-chloromethyl-thiazol-2-yl)-ethanol (2.19 g, 12.31 mmol) in CH3CN (122 mL) was treated at rt with MnO2 (5.94 g, 61.52 mmol). The reaction mixture was stirred at rt until completion of the reaction, and then filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.84 min.

후처리

  1. filtrationfiltered through Celite
  2. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-79154917368b43f5baddd6744e4b48ad
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563714B2

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