Sodium Bisulfite → 7-Fluoro-2,3-dihydro-1h-indol-2-one

HRID 1045039노트

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HRID 1045039 반응식
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH:7]2SC.S(=O)(O)[O-].[Na+]>O>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2

참가 물질

4

반응물 2

HCID 23665763Sodium BisulfiteHCID 569635307-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 37343717-Fluoro-2,3-dihydro-1h-indol-2-one수율 95%

시약·촉매·용매 1

HCID 962Water용매

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온도
25 °C

실험 절차

7-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one (270.5 g) was dissolved in water (2000 g) and admixed with sodium bisulfite (300 g). The mixture was heated to reflux, in the course of which it was vigorously stirred. After 2.25 h, the mixture was cooled to 25° C. and isolated by filtration on a suction filter. It was washed twice with water (500 g each time) and then dried under reduced pressure (<50 mbar, 50° C.). This gave 7-fluoro-1,3-dihydro-2H-indol-2-one as a white solid (206.3 g, 95.1% by weight, 95% yield).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux, in the course of which it
  3. customisolated by filtration on a suction
  4. filtrationfilter
  5. washIt was washed twice with water (500 g each time)
  6. customdried under reduced pressure (<50 mbar, 50° C.)

출처 및 근거

ORD 기록
ord-55c6420b1cdb4957ae254223264664a4
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563749B2

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