Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 4-Chlorobenzhydrol, (S)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 반응물 | 4-Chlorobenzenebromide | HCID 86664079 | — |
| 반응물 | HCID 178418255 | HCID 178418255 | — |
| 반응물 | HCID 178478191 | HCID 178478191 | — |
| 생성물 | 4-Chlorobenzhydrol, (S)- | HCID 852995 | — |
반응 단계
An operation was carried out in the same manner as in Example 14, except that 0.29 mL (0.375 mmol) of 4-chlorophenylmagnesium bromide (1.4 mol/L) prepared from magnesium and 4-chlorobenzene bromide was used instead of the anhydrous THF solution of phenylmagnesium bromide. Thus, (S)-4-chlorobenzhydrol was obtained. The conversion rate of the raw material was 96%, while the enantiomeric excess was 92% ee.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08563786B2 |
| 출처 데이터셋 | uspto-grants-2013_10 |
| ORD ID | ord-9e34341444364e5dadce0824d5b68431 |
| 출처 메모 | uspto-grants-2013_10 |