Acetic Acid → 10-chloro-6, 10b-dihydro-2H-oxazolo[3,2-c]pyrido[3,2-e]pyrimidin-5 (3H)-one

반응식

C(O[C:6](=[O:17])[NH:7][C:8]1[C:13]([CH:14]=[O:15])=[C:12]([Cl:16])[CH:11]=[CH:10][N:9]=1)(C)(C)C.[NH2:18][CH2:19][CH2:20]O.CC(O)=O>C1(C)C=CC=CC=1>[Cl:16][C:12]1[C:13]2[CH:14]3[O:15][CH2:20][CH2:19][N:18]3[C:6](=[O:17])[NH:7][C:8]=2[N:9]=[CH:10][CH:11]=1

참가 물질

실험 절차

tert-Butyl(4-chloro-3-formylpyridin-2-yl)carbamate (2.0 g, 7.79 mmol), 2-aminoethanol (0.57 g, 9.35 mmol), and AcOH (0.47 g; 7.79 mmol) were suspended in toluene (20 mL), and stirred overnight at room temperature. The reaction mixture was concentrated, and suspended in hexanes/ether (5/1, v/v). The resulting precipitate was filtered, suspended in NMP (3 mL) in 20 ml seal tube, and heated for 30 min. at 150° C. The crude product was purified directly via HPLC to provide 42 (270 mg, 10% yield) as a solid. LC-MS (M+H=226, obsd.=226).