5-[(3-amino-1-methyl-1H-indazol-6-yl)oxy]-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one → 5-(3-Amino-1-methyl-1H-indazol-6-yloxy)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one

참여 물질

역할	이름	HCID	투입량
반응물	5-[(3-amino-1-methyl-1H-indazol-6-yl)oxy]-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one	HCID 70497185	—
용매	Trifluoroacetic acid	HCID 6422	—
생성물	5-(3-Amino-1-methyl-1H-indazol-6-yloxy)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one	HCID 66926243	91.3%

반응 조건

온도	75 °C

반응 단계

Compound 276 (25.00 mg; 0.06 mmol; 1.00 eq.) was dissolved in trifluoroacetic acid (2.00 ml). The vessel was sealed and heated at 75 degrees C. for two days. The reaction was concentrated, redissolved in DMSO, treated with Et3N to get pH ˜8, and then purified via prep HPLC to afford 17mg (69%) of 277 as a white solid. LC-MS (M+H=311, obsd.=311).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08569295B2
출처 데이터셋	uspto-grants-2013_10
ORD ID	ord-5a7ae7da25594a88a6ea16db24a514cd
출처 메모	uspto-grants-2013_10