Methyl 3-chloro-2-oxopropanoate → 2-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

반응식

[CH3:1][O:2][C:3](=[O:8])[C:4](=O)[CH2:5]Cl.[N+:9]([C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:20]=1[NH:19][C:18]([C:21](=[S:23])[NH2:22])=[CH:17]2)([O-:11])=[O:10]>>[CH3:1][O:2][C:3]([C:4]1[N:22]=[C:21]([C:18]2[NH:19][C:20]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][C:12]=3[N+:9]([O-:11])=[O:10])[S:23][CH:5]=1)=[O:8]

참가 물질

반응물 2

HCID 12530121Methyl 3-chloro-2-oxopropanoate

HCID 579018667-nitro-1H-indole-2-carbothioamide

생성물 1

HCID 1363372002-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

실험 절차

3-Chloro-2-oxo-propionic acid methyl ester and 7-nitro-1H-indole-2-carbothioic acid amide prepared in Step A of Preparation 110 were reacted according to the same procedure as Preparation 110 to give the title compound.

후처리

customwere reacted
customaccording to the same procedure as Preparation 110

출처 및 근거

ORD 기록: ord-e5b63f360e7a4bf096747d2247f42503
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08569307B2

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