Acetic Acid → Ethyl 2-cyano-3-ethoxy-2-butenoate

HRID 1046017

반응식

HRID 1046017 반응식
[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].C([C:11](CC)(CC)[C:12]([O-:15])([O-])[O-])C.[C:20](O)(=O)[CH3:21]>>[C:1]([C:3](=[C:20]([O:15][CH2:12][CH3:11])[CH3:21])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2]

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 7764Ethyl cyanoacetateHCID 21875354Triethylorthoaceate

생성물 1

HCID 46635Ethyl 2-cyano-3-ethoxy-2-butenoate

반응 조건

온도
125 °C

실험 절차

A mixture of ethyl 2-cyanoacetate (120 g, 1.06 mol) and triethylorthoacetate (354 g, 2.12 mol) in glacial acetic acid (33 g, 0.53 mol) was stirred at 120-130° C. overnight. The mixture was concentrated under vacuum to provide crude ethyl 2-cyano-3-ethoxybut-2-enoate. The residue was carried into the next reaction without further purification assuming 100% conversion.

후처리

  1. concentrationThe mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-90f1f1cbda74454492aa043b75d3489e
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569319B2

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