(5-Allyloxy-2-nitro-phenyl)-(4-isopropyl-phenyl)-methanone → (5-Allyloxy-2-amino-phenyl)-(4-isopropyl-phenyl)-methanone

HRID 1046383노트

반응식

HRID 1046383 반응식
[CH2:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:22]([O-])=O)=[C:9]([C:11]([C:13]2[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][CH:14]=2)=[O:12])[CH:10]=1)[CH:2]=[CH2:3]>C(O)(=O)C.[Fe]>[CH2:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([NH2:22])=[C:9]([C:11]([C:13]2[CH:14]=[CH:15][C:16]([CH:19]([CH3:20])[CH3:21])=[CH:17][CH:18]=2)=[O:12])[CH:10]=1)[CH:2]=[CH2:3]

참가 물질

4

반응물 1

HCID 59259161(5-Allyloxy-2-nitro-phenyl)-(4-isopropyl-phenyl)-methanone

생성물 1

HCID 45139629(5-Allyloxy-2-amino-phenyl)-(4-isopropyl-phenyl)-methanone

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매2회

실험 절차

To an ice chilled solution of 16 g (5-allyloxy-2-nitro-phenyl)-(4-isopropyl-phenyl)-methanone in 65 ml acetic acid are added 21.8 g iron powder. A precipitate that is formed is brought into solution by addition of additional acetic acid. After stirring for 16 h at r.t. the reaction mixture is filtered and basified by addition of aqueous potassium hydroxide solution. Extraction with dichloromethane yields (5-allyloxy-2-amino-phenyl)-(4-isopropyl-phenyl)-methanone.

후처리

  1. customA precipitate that is formed
  2. filtrationis filtered
  3. additionbasified by addition of aqueous potassium hydroxide solution
  4. extractionExtraction with dichloromethane

출처 및 근거

ORD 기록
ord-08236a0f7c9245bfb0df416c3895f484
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569317B2

반응 노트

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