Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-[2-hydroxy-2-(2,4,6-trimethyl-phenyl)-ethyl]-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(2,4,6-Trimethylphenyl)oxirane | HCID 12862878 | — |
| 반응물 | 4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one | HCID 59259137 | — |
| 촉매 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-[2-hydroxy-2-(2,4,6-trimethyl-phenyl)-ethyl]-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one | HCID 59259156 | — |
반응 단계
A mixture of 0.5 g (1.57 mmol) 4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one, 0.254 g (1.57 mmol) mesityl oxirane, 35.7 mg (0.157 mmol) benzyltriethylammonium chloride and 21.7 mg (0.157 mmol) potassium carbonate is stirred in 1 ml dioxane at 90° C. for 6 days. The reaction mixture is extracted with water/dichloromethane and, after evaporation of the organic phases, the residue is purified by preparative reversed phase HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08569317B2 |
| 출처 데이터셋 | uspto-grants-2013_10 |
| ORD ID | ord-3ceb0578e44b440aae5758693b6c2558 |
| 출처 메모 | uspto-grants-2013_10 |