Ethanol → HCID 25161047, 화합물

HRID 1047855노트

반응식

HRID 1047855 반응식
C([O:3][C:4]([C:6]1([NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]#[N:24])[C:18]=2[CH3:25])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])C.[OH-].[K+].CCO>O>[C:23]([C:19]1[C:18]([CH3:25])=[C:17]([CH:22]=[CH:21][CH:20]=1)[C:16]([NH:15][C:6]1([C:4]([OH:5])=[O:3])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:26])#[N:24]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 59314291HCID 59314291, 화합물

생성물 1

HCID 25161047HCID 25161047, 화합물수율 95%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

The mixture of 2-(3-cyano-2-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (3) (310 mg, 0.89 mmol), KOH (50% aqueous solution, 2 g, 17.8 mmol), EtOH (10 mL) and water (1 mL) are stirred in a 20 mL vial at 50° C. for 30 min. After concentration in vacuo, the residue is dissolved in water (5 mL) and acidified with conc. HCl until no more white precipitate came out of the water. The filtration affords 2-(3-cyano-2-methyl-benzoylamino)-indan-2-carboxylic acid (238) as white solid (270 mg, 95%).

후처리

  1. concentrationAfter concentration in vacuo
  2. dissolutionthe residue is dissolved in water (5 mL)
  3. filtrationThe filtration

출처 및 근거

ORD 기록
ord-7e9508a68ee94dfe9341de8d24d8de57
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569535B2

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