Sodium Cyanide → 2-(2-Bromo-4-chlorophenyl)acetonitrile

HRID 1047978노트

반응식

HRID 1047978 반응식
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9]Br.[C-:11]#[N:12].[Na+]>C(O)C.O>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:11]#[N:12]

참가 물질

5

반응물 2

HCID 8929Sodium CyanideHCID 106130662-Bromo-1-(bromomethyl)-4-chlorobenzene

생성물 1

HCID 218285012-(2-Bromo-4-chlorophenyl)acetonitrile수율 60.6%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 2-bromo-1-(bromomethyl)-4-chlorobenzene (9.8 g; 34.5 mmol) and sodium cyanide (2.0 g; 41.4 mmol) in 15 mL of 95% ethanol and 2.5 mL water was stirred and heated to reflux. After 30 minutes, the solvent was evaporated and the residue was partitioned between 100 mL ether and 50 mL water. The organic layer was dried over sodium sulfate and evaporated. The residual solid was washed out of the flask with hexane and collected by filtration, washed with hexane, and air-dried on the filter to give 4.82 g of 2-(2-bromo-4-chlorophenyl)acetonitrile as a light yellow solid.

후처리

  1. temperatureheated to reflux
  2. customthe solvent was evaporated
  3. customthe residue was partitioned between 100 mL ether and 50 mL water
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. customevaporated
  6. washThe residual solid was washed out of the flask with hexane
  7. filtrationcollected by filtration
  8. washwashed with hexane
  9. customair-dried on the
  10. filtrationfilter

출처 및 근거

ORD 기록
ord-f4ed9b45f27841a2ba4410f88a412cfe
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569522B2

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