Sodium Methoxide → HCID 44598929, 화합물

HRID 1048182노트

반응식

HRID 1048182 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:32])[NH:20][CH2:21][CH:22]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3Cl)[F:23])=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:33]([OH:35])=[O:34].C[O-].[Na+:38]>CO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:32])[NH:20][CH2:21][CH:22]([C:24]3[CH:25]=[CH:26][C:27]([Cl:30])=[CH:28][CH:29]=3)[F:23])=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:33]([O-:35])=[O:34].[Na+:38]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 67080603HCID 67080603, 화합물

생성물 1

HCID 44598929HCID 44598929, 화합물수율 96.1%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 6-chloro-7-(4-(2-(2,4-dichlorophenyl)-2-fluoroethylcarbamoyl)phenoxy)chroman-4-carboxylic acid (0.122 g, 0.226 mmol) in methanol (2 ml) was added 0.5 M sodium methanolate in methanol (0.476 ml, 0.238 mmol), and the reaction was stirred overnight. The reaction was concentrated, taken up in dichloromethane and hexanes, and concentrated again to yield 122 mg of the title compound as a white solid (96.1% yield). MS (apci) m/z=537.7 (M−Na+2H).

후처리

  1. concentrationThe reaction was concentrated
  2. concentrationhexanes, and concentrated again

출처 및 근거

ORD 기록
ord-ab2ae55c6ef24224a84cf6986b5f98c5
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569522B2

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