Ammonium thiocyanate → 2-(4-Bromo-2-fluorophenyl)-2-oxoethyl thiocyanate

HRID 1048628노트

반응식

HRID 1048628 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9]Br)=[C:4]([F:12])[CH:3]=1.[S-:13][C:14]#[N:15].[NH4+].C(=O)(O)[O-].[Na+]>C(#N)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][S:13][C:14]#[N:15])=[C:4]([F:12])[CH:3]=1

참가 물질

5

반응물 3

HCID 15666Ammonium thiocyanateHCID 516892Sodium BicarbonateHCID 221214832-Bromo-1-(4-bromo-2-fluorophenyl)ethanone

생성물 1

HCID 866186052-(4-Bromo-2-fluorophenyl)-2-oxoethyl thiocyanate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
25 °C

실험 절차

A mixture of the above-mentioned 1-(4-bromo-2-fluorophenyl)-2-bromo-1-ethanone, ammonium thiocyanate 2.15 g and acetonitrile 100 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(4-bromo-2-fluorophenyl)-2-thiocyanato-1-ethanone.

후처리

  1. customTo the reaction mixtures
  2. extractionthe mixtures were extracted with ethyl acetate
  3. washThe organic layers were washed with aqueous saturated sodium bicarbonate solution
  4. dry with materialwere dried over anhydrous sodium sulfate
  5. concentrationThe resulting mixtures were concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1752b023ff794165bdd789db60ee326f
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09380782B2

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