Malic Acid → Apomorphine

HRID 1048685

반응식

HRID 1048685 반응식
[CH3:1][N:2]1[C@@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:20])[C:14]=3[C:9]3[C:10]2=[C:5]([CH:6]=[CH:7][CH:8]=3)[CH2:4][CH2:3]1.O.[C:22]([OH:30])(=[O:29])[CH:23]([CH2:25][C:26]([OH:28])=[O:27])[OH:24]>>[CH3:1][N:2]1[C@@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:20])[C:14]=3[C:9]3[C:10]2=[C:5]([CH:6]=[CH:7][CH:8]=3)[CH2:4][CH2:3]1.[C:22]([O-:30])(=[O:29])[CH:23]([CH2:25][C:26]([O-:28])=[O:27])[OH:24].[CH3:1][N:2]1[C@@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:20])[C:14]=3[C:9]3[C:10]2=[C:5]([CH:6]=[CH:7][CH:8]=3)[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 525Malic AcidHCID 962WaterHCID 6005Apomorphine

생성물 2

HCID 6005ApomorphineHCID 131735991Apomorphine malate

실험 절차

Apomorphine malate solution was prepared by dissolving apomorphine base in 0.1M Malic acid solution. Water was added to obtain solutions with a molar ratio of 1:1 apomorphine:malic acid, at a concentration of 2% apomorphine. The pH of each solution was 4.0. Table 5 shows the composition of each apomorphine organic salt solution.

출처 및 근거

ORD 기록
ord-f504320fed6b4aacb8a6e71e66288196
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09381249B2

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