Bromine → 5-Bromo-2-methoxynicotinonitrile

HRID 1048744

반응식

HRID 1048744 반응식
C([O-])(=O)C.[Na+].[Br:6]Br.[CH3:8][O:9][C:10]1[N:17]=[CH:16][CH:15]=[CH:14][C:11]=1[C:12]#[N:13]>C(O)(=O)C>[Br:6][C:15]1[CH:16]=[N:17][C:10]([O:9][CH3:8])=[C:11]([CH:14]=1)[C:12]#[N:13]

참가 물질

5

반응물 3

HCID 24408BromineHCID 2520992-Methoxypyridine-3-carbonitrileHCID 517045Sodium Acetate

생성물 1

HCID 263699225-Bromo-2-methoxynicotinonitrile수율 73%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
70 °C

실험 절차

12.23 g (149 mmol) of sodium acetate and then 7.66 ml (149 mmol) of bromine at 0° C. are added to 10 g (74.6 mmol) of a solution of 2-methoxy-nicotinonitrile in 29 ml of acetic acid. The reaction mixture is heated at 70° C. overnight. After returning to room temperature, the reaction medium is added to an ice bath and the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 11.6 g (73%) of 5-bromo-2-methoxy-nicotinonitrile in the form of a white solid.

후처리

  1. customAfter returning to room temperature
  2. additionthe reaction medium is added to an ice bath
  3. customthe precipitate obtained
  4. filtrationis filtered
  5. washrinsed with water
  6. customdried at 50° C.

출처 및 근거

ORD 기록
ord-1f45519256d44257bb2a730ed232eafd
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09381195B2

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