Water → 5-Hydroxypyridine-3-carbonitrile
반응식
C[O:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9].Cl.N1C=CC=CC=1.O.C(=O)(O)[O-].[Na+]>C(OCC)C>[OH:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9]참가 물질
6
반응 조건
- 온도
- 200 °C
실험 절차
A mixture of 1 g of 5-methoxynicotinonitrile (7.46 mmol) and 8.62 g of pyridine hydrochloride is heated at 200° C. for 2 hours. The crude reaction product is diluted in a water fraction several times with diethyl ether. The aqueous phase is basified by adding sodium bicarbonate and then extracted again with diethyl ether. The organic phase is dried and then concentrated to yield 850 mg of 5-hydroxynicotinonitrile (95%) in the form of a beige solid.
후처리
- customThe crude reaction product
- extractionextracted again with diethyl ether
- customThe organic phase is dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-ec81dfba4db14ae28f27aa67adb83800
- 출처 데이터셋
- uspto-grants-2016_07
- 특허 번호
- US09381195B2
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