참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Hydroxybenzaldehyde | HCID 126 | — |
| 반응물 | Methyl Ethyl Ketone | HCID 6569 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Dibutylamino-3-chloropropane hydrochloride | HCID 22595053 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(3-Dibutylamino-propoxy)-benzaldehyde | HCID 14146400 | 90.9% |
반응 단계
9.69 g of dibutylamino propylchloride HCl salt (IV) (0.04 mol, 1 eq), 5 g of 4-hydroxybenzaldehyde (III) (0.04 mol, 1 eq), 17 g of potassium carbonate (0.12 mol, 3 eq) and 30 mL of MEK are added to the reaction flask. The suspension is heated to 80° C. and it is stirred for 10 hours at this temperature. Then the mixture is cooled to room temperature, 40 mL of water is added and the brown solution is stirred for 30 min. After phase separation the organic phase is washed with 15 mL of water and the solvent is evaporated to obtain 10.6 g of compound (V) as a yellowish-brown solid (89%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09382223B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_07 |
|---|
| ORD ID | ord-33d6c86450a443948090e15be20b79b6 |
|---|
| 출처 메모 | uspto-grants-2016_07 |
|---|
