Hydrochloride methanol → N-[(5-Isoquinolyl)sulfonyl]-N-(3-phenylpropyl)-1,3-propylenediamine hydrochloride

HRID 10492노트

반응식

HRID 10492 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]([S:22]([C:25]1[CH:34]=[CH:33][CH:32]=[C:31]2[C:26]=1[CH:27]=[CH:28][N:29]=[CH:30]2)(=[O:24])=[O:23])[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=O)(C)(C)C.[ClH:35].CO>>[ClH:35].[CH:30]1[C:31]2[C:26](=[C:25]([S:22]([N:12]([CH2:13][CH2:14][CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:11][CH2:10][CH2:9][NH2:8])(=[O:23])=[O:24])[CH:34]=[CH:33][CH:32]=2)[CH:27]=[CH:28][N:29]=1

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 21979966N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-N'-(3-phenylpropyl)-1,3-propylenediamine

생성물 1

HCID 11293051N-[(5-Isoquinolyl)sulfonyl]-N-(3-phenylpropyl)-1,3-propylenediamine hydrochloride

실험 절차

Intermediate 2 (913 mg) was added with 10% hydrogen chloride/methanol solution (18 ml, Tokyo Kasei Kogyo) at room temperature and stirred for 25 minutes under reflux by heating. After the reaction, the solvent was evaporated under reduced pressure, and the residue was crystallized from a mixed solvent of methanol and diethyl ether to obtain the title compound (653 mg).

후처리

  1. temperatureunder reflux
  2. temperatureby heating
  3. customAfter the reaction
  4. customthe solvent was evaporated under reduced pressure
  5. customthe residue was crystallized from a mixed solvent of methanol and diethyl ether

출처 및 근거

ORD 기록
ord-62100151a08f44888e9b9f008aa8d719
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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