Potassium Hydroxide → 2-Ethoxy-2-methylpropanoic acid

HRID 1049301노트

반응식

HRID 1049301 반응식
[CH2:1]([O:3][C:4]([CH3:10])([CH3:9])[C:5]([O:7]C)=[O:6])[CH3:2].[OH-].[K+]>CO.O>[CH2:1]([O:3][C:4]([CH3:10])([CH3:9])[C:5]([OH:7])=[O:6])[CH3:2]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 22395030HCID 22395030, 화합물

생성물 1

HCID 144596782-Ethoxy-2-methylpropanoic acid수율 76%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

A solution of methyl 2-ethoxy-2-methylpropanoate (1.6 g, 10.95 mmol) in MeOH (14 mL) was treated drop-wise with a solution of KOH (1.228 g, 21.89 mmol) in water (7 mL) and stirred at RT overnight. The mixture was treated with water, washed with Et2O (2×) and the aqueous layer was acidified to pH 2 with 2M HCl. The mixture was extracted with EtOAc (4×) and the combined organics were dried over MgSO4 and concentrated to dryness to afford 2-ethoxy-2-methylpropanoic acid (1.1 g, 76%) as a colorless oil. 1H NMR (400 MHz, DMSO-d6): δ 12.42 (s, 1H), 3.34 (q, J=7.0 Hz, 2H), 1.28 (s, 6H), 1.06 (t, J=7.0 Hz, 3H).

후처리

  1. washwashed with Et2O (2×)
  2. extractionThe mixture was extracted with EtOAc (4×)
  3. dry with materialthe combined organics were dried over MgSO4
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-a837f50bf44f4e8290e7f70652c286fe
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09382228B2

반응 노트

불러오는 중…