Water → 1,1'-[(4-Bromo-1,3-phenylene)bis(oxymethylene)]dibenzene

HRID 1049395노트

반응식

HRID 1049395 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][C:3]=1O.[C:10](=[O:13])([O-])[O-].[K+].[K+].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.O>CN(C=O)C>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([O:6][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:4][C:3]=1[O:13][CH2:10][C:2]1[CH:8]=[CH:7][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 811054-Bromoresorcinol

생성물 1

HCID 128821681,1'-[(4-Bromo-1,3-phenylene)bis(oxymethylene)]dibenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-bromoresorcinol (10.0 g) and potassium carbonate (21.9 g) in DMF (100 mL) was added benzyl bromide (13.2 mL), and the mixture was stirred at room temperature for 4 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (21.8 g) as a crude oil. This compound was used for the next step without further purification.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-71ceb44d36f4475c9258aae541654eff
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09382188B2

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