Hydrochloride methanol → HCID 21979812, 화합물

HRID 10494노트

반응식

HRID 10494 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]([S:23]([C:26]1[CH:35]=[CH:34][CH:33]=[C:32]2[C:27]=1[CH:28]=[CH:29][N:30]=[CH:31]2)(=[O:25])=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C.[ClH:36].CO>>[ClH:36].[CH:31]1[C:32]2[C:27](=[C:26]([S:23]([N:12]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:11][CH2:10][CH2:9][NH2:8])(=[O:24])=[O:25])[CH:35]=[CH:34][CH:33]=2)[CH:28]=[CH:29][N:30]=1

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 21979838N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-N'-(4-phenylbutyl)-1,3-propylenediamine

생성물 1

HCID 21979812HCID 21979812, 화합물

실험 절차

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 6 (249 mg) and 10% hydrogen chloride/methanol solution (5 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (188 mg) as white powdery solid.

후처리

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-40e9753b7e624fac9a959e0125d91815
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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