Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Fibric acid → 5-[4-(2-Methyl-2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Fibric acid | HCID 70343 | — |
| 반응물 | 2-Methyl-2-phenoxypropanoyl chloride | HCID 13111191 | — |
| 반응물 | 5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione | HCID 117699167 | — |
| 생성물 | 5-[4-(2-Methyl-2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione | HCID 117699411 | 101% |
반응 단계
2-Methyl-2-phenoxypropionic acid (34 mg, 0.189 mmol) was made into acid chloride in a conventional manner. By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (30 mg, 0.095 mmol) obtained in Example 1, (3), and 2-methyl-2-phenoxypropionic acid chloride mentioned above, the title compound (46 mg, yield 100%) was obtained in the same manner as that of Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09382236B2 |
| 출처 데이터셋 | uspto-grants-2016_07 |
| ORD ID | ord-45d02ea71e07441a86152a3515942101 |
| 출처 메모 | uspto-grants-2016_07 |