Hydrochloride methanol → N-[(1-Amino-5-isoquinolyl)sulfonyl]-N-[2-(phenylsulfonyl)ethyl]ethylenediamine hydrochloride

HRID 10500노트

반응식

HRID 10500 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([S:12]([N:15]([CH2:26][CH2:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])[CH2:16][CH2:17][NH:18]C(OC(C)(C)C)=O)(=[O:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[ClH:37].CO>C(OCC)C>[ClH:37].[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([S:12]([N:15]([CH2:26][CH2:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])[CH2:16][CH2:17][NH2:18])(=[O:13])=[O:14])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 21979800N-[(1-amino-5-isoquinolyl)sulfonyl]-N'-(tert-butoxycarbonyl)-N-[2-(phenylsulfonyl)ethyl]ethylenediamine

생성물 1

HCID 21979847N-[(1-Amino-5-isoquinolyl)sulfonyl]-N-[2-(phenylsulfonyl)ethyl]ethylenediamine hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 17 (134 mg) and 10% hydrogen chloride/methanol solution (2.5 ml). The reaction mixture was cooled to room temperature and then added with diethyl ether (2.5 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (100 mg) as white powdery solid.

후처리

  1. custom(50° C., 2 hours)
  2. customThe deposited precipitates
  3. filtrationwere collected by filtration
  4. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-cfd70b3b3b30460cbdf9d354bc36adca
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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