참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Bromoisoquinoline | HCID 736487 | — |
| 반응물 | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| 반응물 | tert-butyl N-(3-aminopropyl)-N-methylcarbamate | HCID 2756543 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-(tert-butoxycarbonyl)-N-methyl-N'-(5-isoquinolyl)-1,3-propylenediamine | HCID 21979883 | 85.1% |
반응 단계
Under nitrogen atmosphere, a suspension of 5-bromoisoquinoline (252 mg), tris(dibenzylideneacetone)palladium(0) (59 mg), 2-(di-tert-butylphosphino)biphenyl (74 mg), (3-aminopropyl)methylcarbamic acid tert-butyl ester (274 mg, Asta Tech), and sodium tert-butoxide (163 mg) in toluene was stirred with heating at 70° C. for 3 hours. The reaction mixture was returned to room temperature and purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (325 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07094789B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-34859159c1f24492b072bc7bfbc36a45 |
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| 출처 메모 | uspto-grants-2006_08 |
|---|
