Hydrochloride methanol → N-(5-Isoquinolyl)-N'-methyl-1,3-propylenediamine hydrochloride

HRID 10509

반응식

HRID 10509 반응식
C(O[C:6]([N:8](C)[CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][N:17]=[CH:18]2)=O)(C)(C)C.[ClH:24].CO>>[ClH:24].[CH:18]1[C:19]2[C:14](=[C:13]([NH:12][CH2:11][CH2:10][CH2:9][NH:8][CH3:6])[CH:22]=[CH:21][CH:20]=2)[CH:15]=[CH:16][N:17]=1

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 21979883N-(tert-butoxycarbonyl)-N-methyl-N'-(5-isoquinolyl)-1,3-propylenediamine

생성물 1

HCID 21979765N-(5-Isoquinolyl)-N'-methyl-1,3-propylenediamine hydrochloride

실험 절차

According to the method of Example 1, Step C, deprotection was performed (room temperature, 31 hours) by using Intermediate 29 (325 mg) and 10% hydrogen chloride/methanol solution (5 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (273 mg) as light yellow powdery solid.

후처리

  1. custom(room temperature, 31 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-e9e223d3e3e74eb7b824227dc02c0a1d
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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