(3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester → HCID 54100600, 화합물

HRID 1050996노트

반응식

HRID 1050996 반응식
[CH3:1][O:2][C:3](=[O:17])[CH:4]=[C:5]1[CH2:8][CH:7]([NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6]1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:6][CH:7]([NH:9][C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])[CH2:8]1

참가 물질

4

반응물 1

HCID 23374583(3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester

생성물 1

HCID 54100600HCID 54100600, 화합물수율 99.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of (3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester (7 g, 29 mmol) in methanol (100 mL) was added Pd/C (5 g) and stirred at room temperature under H2 balloon overnight. After TLC showed the reaction was completed, the mixture was filtered over Celite. The filtrate was concentrated under reduced pressure to give the title compound (7 g, yield 99%) as a white solid, which was used for the next step directly without further purification.

후처리

  1. filtrationthe mixture was filtered over Celite
  2. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3493d6a7fd5549f1b907aa07869f36c9
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388148B2

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