5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile → 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile

HRID 1051132노트

반응식

HRID 1051132 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]([F:15])([F:14])[F:13])[C:7]([C:10]#[N:11])=[N:8][CH:9]=1)([O-])=O>C(O)(=O)C.[Fe]>[NH2:1][C:4]1[CH:5]=[C:6]([C:12]([F:15])([F:13])[F:14])[C:7]([C:10]#[N:11])=[N:8][CH:9]=1

참가 물질

4

반응물 1

HCID 218748935-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile

생성물 1

HCID 135322465-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile수율 91%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

A mixture of 5-nitro-3-(trifluoromethyl)pyridine-2-carbonitrile 22 and iron powder in acetic acid is heated. 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile, 8 is obtained in a yield of 91%.

후처리

  1. temperatureis heated

출처 및 근거

ORD 기록
ord-2a30136bf05642bf84101be223d8495a
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388159B2

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