Hydrochloride methanol → N~1~-(Isoquinolin-5-yl)pentane-1,5-diamine--hydrogen chloride (1/1)

HRID 10512

반응식

HRID 10512 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1[CH:24]=[CH:23][CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][N:19]=[CH:20]2)=O)(C)(C)C.[ClH:25].CO>>[ClH:25].[CH:20]1[C:21]2[C:16](=[C:15]([NH:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][NH2:8])[CH:24]=[CH:23][CH:22]=2)[CH:17]=[CH:18][N:19]=1

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 21979906N-(tert-butoxycarbonyl)-N'-(5-isoquinolyl)-pentamethylenediamine

생성물 1

HCID 21979922N~1~-(Isoquinolin-5-yl)pentane-1,5-diamine--hydrogen chloride (1/1)

실험 절차

According to the method of the above Example, deprotection was performed (room temperature, 31 hours) by using Intermediate 31 (327 mg) and 10% hydrogen chloride/methanol solution (5 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (262 mg) as light yellow powdery solid.

후처리

  1. custom(room temperature, 31 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-95aa8b8184824c4f92502d147d13a2fb
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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