Flumexadol → HCID 118323819, 화합물

HRID 1051388노트

반응식

HRID 1051388 반응식
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:9]2[O:14][CH2:13][CH2:12][NH:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[F:17][C:18]([F:26])([F:25])[C:19](=[CH2:24])[C:20]([O:22][CH3:23])=[O:21]>>[F:17][C:18]([F:26])([F:25])[CH:19]([CH2:24][N:11]1[CH2:12][CH2:13][O:14][CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=2)[CH2:10]1)[C:20]([O:22][CH3:23])=[O:21]

참가 물질

3

반응물 2

HCID 65774FlumexadolHCID 2782391Methyl 2-(trifluoromethyl)acrylate

생성물 1

HCID 118323819HCID 118323819, 화합물

실험 절차

In a 5 mL round-bottomed flask, 2-(3-(trifluoromethyl)phenyl)morpholine (650 mg, 2.81 mmol) was combined with methyl 2-(trifluoromethyl)acrylate (650 mg, 4.22 mmol; added slowly) to give a colorless solution and stirred at room temperature for 50 min. The crude reaction mixture was concentrated in vacuo to give an oil. The crude material was purified by flash chromatography (silica gel, 40+S, 0% to 30% ethyl acetate in hexanes) to afford 850 mg (78%)(methyl 3,3,3-trifluoro-2-((2-(3-(trifluoromethyl)phenyl)morpholino)-methyl)propanoate as a clear liquid. MH+=386.

후처리

  1. additionadded slowly)
  2. customto give a colorless solution
  3. customThe crude reaction mixture
  4. concentrationwas concentrated in vacuo
  5. customto give an oil
  6. customThe crude material was purified by flash chromatography (silica gel, 40+S, 0% to 30% ethyl acetate in hexanes)

출처 및 근거

ORD 기록
ord-2bef9af9fcde4139945c44cbef9bcdcf
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388172B2

반응 노트

불러오는 중…