Ammonium → 1-amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
반응식
[O:1]1[CH2:3][CH:2]1[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1.[NH4+:15]>C(O)C>[NH2:15][CH2:3][CH:2]([OH:1])[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
A sealed vessel was charged with 2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline (1.5 g, 7.9 mmol) and ammonium in ethanol (50 mL) was then added and the vessel sealed and heated at 80° C. for 2 h. After cooling to room temperature, solvents were evaporated to afford the desired product as a colorless oil (1.2 g, 73.7% yield). It was used in the next step without further purification. LCMS (m/z): 207.1 [M+H]+
후처리
- additionwas then added
- customthe vessel sealed
- temperatureAfter cooling to room temperature
- customsolvents were evaporated
출처 및 근거
- ORD 기록
- ord-660629a00f30441ea077fe96b897c747
- 출처 데이터셋
- uspto-grants-2016_07
- 특허 번호
- US09388173B2
반응 노트
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