Hydrogen chloride-ethyl acetate → HCID 14689279, 화합물

HRID 1051485노트

반응식

HRID 1051485 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][CH:12]([OH:29])[CH2:13][O:14][C:15]1[CH:16]=[C:17]([NH:21]C(=O)OC(C)(C)C)[CH:18]=[CH:19][CH:20]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[NH2:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[O:14][CH2:13][CH:12]([OH:29])[CH2:11][N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86729264HCID 86729264, 화합물

생성물 1

HCID 14689279HCID 14689279, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of tert-butyl (3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)phenyl)carbamate (1.2 g, 3.01 mmol) in ethyl acetate (30 mL) was added HCl/ethyl acetate (20 mL). The reaction mixture was stirred at room temperature for 2 h. and the concentrated with the residue used in the next step without further purification.

후처리

  1. concentrationthe concentrated with the residue
  2. customused in the next step without further purification

출처 및 근거

ORD 기록
ord-f99364bb721544b9b713db57a1eac618
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388173B2

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