Water → Di-tert-butyl ((6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl) phosphate

반응식

[F:1][C:2]1[C:3]([NH:21][C:22]2[CH:23]=[CH:24][C:25]3[O:26][C:27]([CH3:34])([CH3:33])[C:28](=[O:32])[NH:29][C:30]=3[N:31]=2)=[N:4][C:5]([NH:8][C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)=[N:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[P:41]([O:53][CH2:54]Cl)([O:48][C:49]([CH3:52])([CH3:51])[CH3:50])([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42].O>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.CN(C)C(=O)C.C(OC(C)C)(=O)C>[P:41]([O:53][CH2:54][N:29]1[C:28](=[O:32])[C:27]([CH3:34])([CH3:33])[O:26][C:25]2[CH:24]=[CH:23][C:22]([NH:21][C:3]3[C:2]([F:1])=[CH:7][N:6]=[C:5]([NH:8][C:9]4[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=4)[N:4]=3)=[N:31][C:30]1=2)([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])([O:48][C:49]([CH3:50])([CH3:51])[CH3:52])=[O:42]