Potassium Carbonate → tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate

HRID 1052097노트

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HRID 1052097 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=[O:12])[CH3:11])=[N:2]1.C([O-])([O-])=O.[K+].[K+].Br[CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22]>CC#N>[C:10]([C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[N:1]([CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[N:2]=1)(=[O:12])[CH3:11]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 156841691-(1H-indazol-3-yl)ethan-1-one

생성물 1

HCID 68283733tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
90 °C

실험 절차

To a solution of 1-(1H-indazol-3-yl)ethanone [4498-72-0](2 g, 12.46 mmol) in CH3CN (50 mL) was added K2CO3 (3.97 g, 28.7 mmol) and tert-butyl 2-bromoacetate (2.58 mL, 17.48 mmol). The reaction mixture was stirred at 90° C. overnight. The reaction mixture was filtered, the residue was washed with CH3CN and the filtrate was concentrated under vacuum. The material thus obtained was used directly in the next step without further purification. MS: 275 [M+H]+; tR (HPLC conditions d): 3.78 min.

후처리

  1. filtrationThe reaction mixture was filtered
  2. washthe residue was washed with CH3CN
  3. concentrationthe filtrate was concentrated under vacuum
  4. customThe material thus obtained
  5. customwas used directly in the next step without further purification
  6. custom3.78 min.

출처 및 근거

ORD 기록
ord-f8492ef54865488ab95c427deb04f006
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388199B2

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