Trifluoroacetic acid → 2-(3-Acetyl-1H-indazol-1-yl)acetic acid

HRID 1052098노트

반응식

HRID 1052098 반응식
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl.CO>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 68283733tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate

생성물 1

HCID 682847152-(3-Acetyl-1H-indazol-1-yl)acetic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매2회

실험 절차

To a solution of tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate (4 g, 12.4 mmol) in CH2Cl2 (45 mL) was added TFA (15 mL, 195.0 mmol), and the reaction mixture was stirred at RT overnight. Then was then diluted with CH2Cl2 and MeOH, and volatiles were evaporated under reduced pressure to afford the title compound: MS: 219 [M+H]+; tR (HPLC conditions d): 2.78 min.

후처리

  1. customwere evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-c9ec591230b244e9bc7792b5d70bb29e
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388199B2

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