Trifluoroacetic acid → 1386457-64-2

HRID 1052105노트

반응식

HRID 1052105 반응식
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68283122Tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate

생성물 1

HCID 682833421386457-64-2

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate (3.42 g, 12.4 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol) and the resulting mixture was stirred at RT for 16 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in MeOH and concentrated again in vacuo to give the title compound. MS (LC/MS): 220 [M+H]+; tR (HPLC conditions d): 1.79 min.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. concentrationconcentrated again in vacuo

출처 및 근거

ORD 기록
ord-3c8f59bfd65f40498ef28df1629718b6
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388199B2

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