5-Bromo-2-ethoxypyridin-3-amine → N-(5-Bromo-2-ethoxypyridin-3-yl)-4-hydroxy-3-methylbenzenesulfonamide

반응식

[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1.[OH:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][C:14]=1[CH3:23]>>[Br:1][C:2]1[CH:3]=[C:4]([NH:11][S:19]([C:16]2[CH:17]=[CH:18][C:13]([OH:12])=[C:14]([CH3:23])[CH:15]=2)(=[O:21])=[O:20])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 532116995-Bromo-2-ethoxypyridin-3-amine

HCID 552806724-Hydroxy-3-methylbenzene-1-sulfonyl chloride

생성물 1

HCID 90103249N-(5-Bromo-2-ethoxypyridin-3-yl)-4-hydroxy-3-methylbenzenesulfonamide수율 100%

실험 절차

5-Bromo-2-ethoxypyridin-3-amine (506 mg, 2.33 mmol) was treated with 4-hydroxy-3-methylbenzene-1-sulfonyl chloride (506 mg, 2.45 mmol, prepared as described at JP 47015818 B4 19720511) according to the method described in Preparation 15b to give 902 mg (100% yield) of the title compound as an oil. Purity 99%.

출처 및 근거

ORD 기록: ord-d0452207c47942778cf9b7ff98711939
출처 데이터셋: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09388189B2

반응 노트

불러오는 중…