Triethylamine → HCID 90103295, 화합물

반응식

[Br:1][C:2]1[CH:10]=[C:9]([NH2:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.[CH3:12][S:13](Cl)(=[O:15])=[O:14].C(N(CC)CC)C>>[Br:1][C:2]1[CH:10]=[C:9]([NH:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

참가 물질

반응물 3

HCID 8471Triethylamine

HCID 31297Methanesulfonyl chloride

HCID 247280674-Bromo-1H-indazol-6-amine

생성물 1

HCID 90103295HCID 90103295, 화합물수율 61.5%

실험 절차

4-Bromo-1H-indazol-6-amine (500 mg, 2.36 mmol) was treated with methanesulfonyl chloride (130 μl, 1.68 mmol) and triethylamine (49 μl, 3.55 mmol) according to the method described in Preparation 15b. The residue was purified using SP1® Purification System to give 300 mg (49% yield) of the title compound. Purity 80%.