홈 MCP 워크벤치 Skills

홈 워크벤치 알림 마이페이지

llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

홈
반응

Ammonia → 5-methyl-3-phenyl-2-[(1S)-1-[[5-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-one

HRID 1052679

인쇄 미리보기

반응식

HRID 1052679 반응식

[NH:1]1[CH:5]=[C:4]([C:6]2[C:14]3[C:13]([NH:15][C@H:16]([C:18]4[N:23]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[C:22](=[O:30])[C:21]5=[C:31]([CH3:34])[CH:32]=[CH:33][N:20]5[N:19]=4)[CH3:17])=[N:12][CH:11]=[N:10][C:9]=3[N:8](COCC[Si](C)(C)C)[CH:7]=2)[CH:3]=[N:2]1.FC(F)(F)C(O)=O.N>>[NH:1]1[CH:5]=[C:4]([C:6]2[C:14]3[C:13]([NH:15][C@H:16]([C:18]4[N:23]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[C:22](=[O:30])[C:21]5=[C:31]([CH3:34])[CH:32]=[CH:33][N:20]5[N:19]=4)[CH3:17])=[N:12][CH:11]=[N:10][C:9]=3[NH:8][CH:7]=2)[CH:3]=[N:2]1

참가 물질 실험 절차 출처 및 근거 반응 노트

참가 물질

4

반응물 3

HCID 222Ammonia

HCID 6422Trifluoroacetic acid

HCID 131736135(S)-2-(1-((5-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

생성물 1

HCID 737769315-methyl-3-phenyl-2-[(1S)-1-[[5-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-one수율 66.4%

실험 절차

(S)-2-(1-((5-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (23 mg, 0.04 mmol) was treated with trifluoroacetic acid (460 μl, 5.97 mmol) and a solution of ammonia (7N in methanol, 460 μl, 3.22 mmol) according to the method described in Example 27 to give 12 mg (66% yield) of the title compound. Purity 98%.

출처 및 근거

ORD 기록: ord-ae6b34f89aa546d980f3e4b116d048ea
출처 데이터셋: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09388189B2

반응 노트

불러오는 중…

이 페이지에서참가 물질 실험 절차 출처 및 근거 반응 노트