Hydrochloride methanol → N-(4-Methylthio-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

HRID 10535노트

반응식

HRID 10535 반응식
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([S:26][CH3:27])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[ClH:28].[CH3:27][S:26][C:18]1[C:17]2[C:22](=[CH:23][CH:24]=[CH:25][C:16]=2[NH:15][CH:12]2[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]2)[CH:21]=[N:20][CH:19]=1

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 21979943N-(tert-butoxycarbonyl)-N'-(4-methylthio-5-isoquinolyl)-1,4-cyclohexanediamine

생성물 1

HCID 21979853N-(4-Methylthio-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

실험 절차

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 78 (341 mg) and 10% hydrogen chloride/methanol solution (5 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (2 ml) and diethyl ether (6 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (279 mg).

후처리

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (2 ml) and diethyl ether (6 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-b59867340aaa44959c4661c4e65259c3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

반응 노트

불러오는 중…