Trifluoroacetic acid → Phenyl pyrrolidine-3-carboxylate

HRID 1053522노트

반응식

HRID 1053522 반응식
N1CCCC1C(OC1C=CC=CC=1)=O.C(O)(C(F)(F)F)=O.[N:22]1(C(OC(C)(C)C)=O)[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1>>[NH:22]1[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 15598566Phenyl pyrrolidine-2-carboxylateHCID 898737321-tert-Butyl 3-phenyl pyrrolidine-1,3-dicarboxylate

생성물 1

HCID 69577543Phenyl pyrrolidine-3-carboxylate

실험 절차

The compound 25 was prepared according to the method described for compound 23 employing TFA (0.66 mL, 8.58 mmol) and compound 24 (500 mg, 1.71 mmol) to give white solid compound. The compound was used without further purification after solvent removal.

후처리

  1. customto give white solid compound
  2. customThe compound was used without further purification
  3. customafter solvent removal

출처 및 근거

ORD 기록
ord-0f001729c14f4ad6807ebbd1657c1e36
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09393306B2

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