tert-Butylsulfinamide, (R)-(+)- → HCID 178465718, 화합물

HRID 1053684노트

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HRID 1053684 반응식
[CH3:1][C:2]([S@:5]([NH2:7])=[O:6])([CH3:4])[CH3:3].[Br:8][C:9]1[C:10]([CH3:18])=[C:11]([C:15](=O)[CH3:16])[CH:12]=[CH:13][CH:14]=1>C1COCC1.C(O[Ti](OCC)(OCC)OCC)C>[Br:8][C:9]1[C:10]([CH3:18])=[C:11](/[C:15](=[N:7]/[S@@:5]([C:2]([CH3:4])([CH3:3])[CH3:1])=[O:6])/[CH3:16])[CH:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 204801311-(3-Bromo-2-methylphenyl)ethanone

생성물 1

HCID 178465718HCID 178465718, 화합물

시약·촉매·용매 2

HCID 178477244HCID 178477244, 화합물촉매HCID 8028Tetrahydrofuran용매

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온도
75 °C

실험 절차

To a stirring solution of (R)-2-methylpropane-2-sulfinamide (326 mg, 2.69 mmol) and Intermediate 12A (600 mg, 2.82 mmol) in THF (2 mL) at rt was added tetraethoxytitanium (1.06 mL, 5.12 mmol). The reaction mixture was heated at 75° C. for 16 h. The reaction mixture was cooled and used directly in the next step. LCMS=2.12 min [M+1]=318.0 (Method B).

후처리

  1. temperatureThe reaction mixture was cooled
  2. customLCMS=2.12 min [M+1]=318.0 (Method B)

출처 및 근거

ORD 기록
ord-d892c17472244c0eb000762b3c79055c
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394260B2

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