Trifluoroacetic acid → 4-[({(2S,4S)-1-[(1-carbamimidoyl-4-piperidinyl)carbonyl]-4-[4-(methylsulfonyl)-1-piperazinyl]-2-pyrrolidinyl}carbonyl)amino]benzoic acid bis(trifluoroacetate)

HRID 1053816노트

반응식

HRID 1053816 반응식
CC(OC([NH:8][C:9]([N:18]1[CH2:23][CH2:22][CH:21]([C:24]([N:26]2[CH2:30][C@@H:29]([N:31]3[CH2:36][CH2:35][N:34]([S:37]([CH3:40])(=[O:39])=[O:38])[CH2:33][CH2:32]3)[CH2:28][C@H:27]2[C:41]([NH:43][C:44]2[CH:56]=[CH:55][C:47]([C:48]([O:50]C(C)(C)C)=[O:49])=[CH:46][CH:45]=2)=[O:42])=[O:25])[CH2:20][CH2:19]1)=[N:10]C(OC(C)(C)C)=O)=O)(C)C.[F:57][C:58]([F:63])([F:62])[C:59]([OH:61])=[O:60]>ClCCl>[F:57][C:58]([F:63])([F:62])[C:59]([OH:61])=[O:60].[F:57][C:58]([F:63])([F:62])[C:59]([OH:61])=[O:60].[C:9]([N:18]1[CH2:19][CH2:20][CH:21]([C:24]([N:26]2[CH2:30][C@@H:29]([N:31]3[CH2:36][CH2:35][N:34]([S:37]([CH3:40])(=[O:39])=[O:38])[CH2:33][CH2:32]3)[CH2:28][C@H:27]2[C:41]([NH:43][C:44]2[CH:45]=[CH:46][C:47]([C:48]([OH:50])=[O:49])=[CH:55][CH:56]=2)=[O:42])=[O:25])[CH2:22][CH2:23]1)(=[NH:8])[NH2:10]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 1317363002-methyl-2-propanyl 4-[({(2S,4S)-1-{[1-(N,N'-bis{[(2-methyl-2-propanyl)oxy]carbonyl}carbamimidoyl)-4-piperidinyl]carbonyl}-4-[4-(methylsulfonyl)-1-piperazinyl]-2-pyrrolidinyl}carbonyl)amino]benzoate

생성물 1

HCID 1181076974-[({(2S,4S)-1-[(1-carbamimidoyl-4-piperidinyl)carbonyl]-4-[4-(methylsulfonyl)-1-piperazinyl]-2-pyrrolidinyl}carbonyl)amino]benzoic acid bis(trifluoroacetate)수율 40%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of the compound prepared in Example 8 (0.11 g, 0.13 mmol) in dichloromethane (15 mL) at 0° C. was added trifluoroacetic acid (0.5 mL). The reaction was warmed to room temperature and stirred for 18 h. The solvent and excess trifluoroacetic acid was removed under reduced pressure. The solid was dissolved in water and lyophilized to dryness to afford the title compound (0.030 g, 40%) as an off-white solid.

후처리

  1. customThe solvent and excess trifluoroacetic acid was removed under reduced pressure
  2. dissolutionThe solid was dissolved in water

출처 및 근거

ORD 기록
ord-7593e35dfcb74a7ab3f40c3a06977b27
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394250B2

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